NCI-COG Pediatric MATCH

NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

Arms / Cohorts

Experimental:Cohort M: HRAS Gene Alterations

Accepting patients

Experimental:Cohort A: NTRK1, NTRK2, or NTRK3 Gene Fusion

Accepting patients

Experimental:Subprotcol M (HRAS gene alterations)

Accepting patients

Experimental:Subprotocol A (NTRK1, NTRK2, or NTRK3 gene fusion)

Accepting patients

Experimental:Cohort B: FGFR1, FGFR2, FGFR3, or FGFR4 Gene Mutation

Accepting patients

Experimental:Cohort C: EZH2, SMARCB1, or SMARCA4 Gene Mutation

Accepting patients

EXPERIMENTAL: Subprotocol B (FGFR1, FGFR2, FGFR3, or FGFR4 gene mutation)

Accepting patients

Experimental:Cohort D: TSC1, TSC2, or PI3K/mTOR Gene Mutation

Accepting patients

EXPERIMENTAL: Subprotocol C (EZH2, SMARCB1, or SMARCA4 gene mutation)

Accepting patients

Experimental:Cohort E: Activating MAPK Pathway Gene Mutation

Accepting patients

EXPERIMENTAL: Subprotocol D (TSC1, TSC2, or PI3K/mTOR gene mutation)

Accepting patients

Experimental:Cohort F: ALK or ROS1 Gene Alteration

Accepting patients

EXPERIMENTAL: Subprotocol E (activating MAPK pathway gene mutation)

Accepting patients

Experimental:Cohort G: BRAF V600 gene mutation

Accepting patients

EXPERIMENTAL: Subprotocol F (ALK or ROS1 gene alteration)

Accepting patients

Experimental:Cohort H: ATM, BRCA1, BRCA2, RAD51C, RAD51D Mutations

Accepting patients

EXPERIMENTAL: Subprotocol G (BRAF V600 gene mutation)

Accepting patients

Experimental:Cohort I: Rb Positive, Alterations in Cell Cycle Genes

Accepting patients

EXPERIMENTAL: Subprotocol H (ATM, BRCA1, BRCA2, RAD51C, RAD51D mutations)

Accepting patients

Experimental:Cohort J: MAPK Pathway Mutations

Accepting patients

EXPERIMENTAL: Subprotocol I (Rb positive, alterations in cell cycle genes)

Accepting patients

Experimental:Cohort N: Activating RET Mutations

Accepting patients

EXPERIMENTAL: Subprotocol J (MAPK pathway mutations)

Accepting patients

EXPERIMENTAL: Subprotocol N (activating RET mutations)

Accepting patients

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