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Accepting patients

TAPUR

Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer (TAPUR)
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  • ROS1 Inhibitor
  • Phase 2

Accepting patients

CARE Study

A Phase 1/2, Open-Label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects With Advanced or Metastatic Malignancies Harboring ALK, ROS1, NTRK1-3 Alterations
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  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1/2
  • Has results
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Accepting patients

Cabozantinib

A Phase II Study of Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity
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  • Tyrosine Kinase (TK) Inhibitor
  • Phase 2
  • Has results

Accepting patients

Larotrectinib

A Phase II Basket Study of the Oral TRK Inhibitor Larotrectinib (BAY2757556) in Subjects With NTRK Amplification Positive and Pan-TRK Positive Tumors
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  • Tyrosine Kinase (TK) Inhibitor
  • Phase 2

Accepting patients

ON-TRK

PrOspective Non-interventional Study in Patients With Locally Advanced or Metastatic TRK Fusion Cancer Treated With Larotrectinib
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  • Tyrosine Kinase (TK) Inhibitor

Accepting patients

Genomically-Guided Treatment Trial in Brain Metastases
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  • PI3K Inhibitor
  • Tyrosine Kinase (TK) Inhibitor
  • CDK6
  • Phase 2

Accepting patients

VMD-928

An Open-Label, Multiple-Dose, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of VMD-928 in Subjects With Solid Tumors or Lymphoma
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  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1

Accepting patients

Larotrectinib

A Pilot and Surgical Study of Larotrectinib for Treatment of Children With Newly-Diagnosed High-Grade Glioma With NTRK Fusion
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  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1

Accepting patients

TRIDENT-1

A Phase 1/2, Open-Label, Multi-Center, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of TPX-0005 in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements (TRIDENT-1)
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  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1/2
  • Has results

Accepting patients

TY-2136b

A Phase I, Multicenter, Open-label Study of TY-2136b, Administered Orally in Patients With Advanced or Metastatic Solid Tumors Harboring ALK, ROS1 or NTRK1-3 Alterations
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  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1