NCI-COG Pediatric MATCH
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol
What's the purpose of the trial?
Accepting patients
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Participating Centers
There are 160 centers participating in this trial. Enter a location below to find the closest center.
Experimental Treatments
Learn more about the experimental treatments being evaluated in this clinical trial.
- Ensartinib
- Erdafitinib is a small molecule FGFR inhibitor that can work by slowing cancer cell growth and reproduction.
- LY3023414
- Larotrectinib is a first generation tropomyosin kinase (TRK) inhibitor used in the treatment of cancers that have TRK fusions.
- Olaparib
- Palbociclib is an oral drug that inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), blocking retinoblastoma (Rb) protein phosphorylation that leads to cell cycle arrest and cancer cell death.
- Samotolisib
- Selpercatinib is a targeted therapy used to treat patients with non-small cell lung cancer (NSCLC) due to RET gene rearrangements.
- Selumetinib is a MEK 1/2 inhibitor used in pediatric patients.
- Selumetinib Sulfate
- Tazemetostat is an EZH2 inhibitor that helps stop the spread of cancer cells.
- Tipifarnib
- Ulixertinib
- Vemurafenib is a BRAF kinase inhibitor that is commonly used in the treatment of certain kinds of melanoma.
Arms / Cohorts
Explore eligibility, treatments and learn more about potential cohorts.
Accepting patients
Accepting patients
Accepting patients
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