A Multicenter, Open-label, Phase Ia/Ib Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of TSN084 Tablets in Patients With Advanced Malignant Tumors.

What's the purpose of the trial?

TSN084 is a novel type II protein kinase inhibitor with demonstrated anti-tumor effects in vitro and in vivo and targets multiple tyrosine kinases, such as c-MET, FLT3, TRK and serine/threonine kinase CDK8/19. This first-in-human study is conducted to assess the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT), to evaluate the pharmacokinetics, safety and preliminary anti-tumor activity of TSN084 in advanced or metastatic malignancies.
Trial status

Accepting patients

Phase
Phase 1
Enrollment
74
Last Updated
11 months ago
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Participating Centers

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Experimental Treatments

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  • TSN084 is a multiple kinase inhibitor being studied for use in several different solid tumors.

Arms / Cohorts

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Accepting patients

TSN084

Accepting patients

EXPERIMENTAL: TSN084

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